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I have to tell you that there is no ideal food it all depends what suites your puppy. There are expensive food and cheep foods. Just because its expensive doesn't mean that it is good. I always tell people to follow their vets advice.

I have read some  horror stories in the past about what goes into the cheep foods and I do believe that people should know as these foods can shorten your puppies life.

Words fail me ......read and find out why

 

Comparing Dog Foods

Types of Dog Foods

The three main types of dog foods are dry, soft-moist and canned products. These vary in a number of characteristics including moisture, cost, palatability and amount of nutrition delivered per pound or ounce of food. Evaluating a dog food diet should include consideration of all these factors. In spite of these variations, with today's advanced technology, all types of dog food products can be formulated to provide complete and balanced nutrition for dogs.

Canned Diets

These diets offer the highest palatability when compared to the dry and soft-moist products. Once a can is opened, unused food should be stored in the refrigerator in a covered container for no longer than three days.

Dry Diets

Dry products consist of crunchy kibbles, which help reduce the build-up of plaque and tartar on a dog's teeth. Dry foods also have the advantage of staying fresh longer than soft-moist and canned products once the package is opened.

Soft-Moist Diets

Soft-moist dog foods generally offer higher palatability as compared to dry diets, are convenient to serve and store easily. They can be more expensive to feed than dry diets.

Targeted Nutrition

These foods are specially formulated and proportioned to meet the special nutritional needs of certain dogs.

Diets designed specifically for puppies usually contain higher levels of the nutrients puppies need during their period of rapid growth and development. Other dog foods are formulated to have higher levels of protein and calories to provide extra energy for puppies, working and hunting dogs. Other dog foods are formulated to be lower in calories and fat to help less active and older dogs maintain normal body weight

(Don't read if you have a weak stomach)

What's Really for Dinner?

The Truth About Commercial Pet Food

by Tina Perry

Cow brains. Sheep guts. Chicken heads. Road kill. Rancid grain. These are a few of the so-called nutritionally balanced ingredients found in the commercial pet food served to companion animals every day.

More than 95 percent of US companion animals derive their nutritional needs from a single source: processed pet food. When people think of pet food, many envision whole chickens, choice cuts of beef, fresh grains, and all the nutrition that a dog or cat may ever need -- images that pet food manufacturers promote in their advertisements. What these companies do not reveal is that instead of whole chickens they have substituted chicken heads, feet, and intestines. Those choice cuts of beef are really cow brains, tongues, esophagi, fetal tissue dangerously high in hormones, and possibly diseased and even cancerous meat. Those whole grains have had the starch removed for corn starch powder and the oil extracted for corn oil, or they are hulls and other remnants from the milling process. Grains used that are truly whole have usually been deemed unfit for human consumption because of mold, contaminants, poor quality, or poor handling practices. Pet food is one of the worlds most synthetic edible products, containing virtually no whole ingredients.

Pet food manufacturers have become masters at inducing companion animals to eat things cat and dogs would normally spurn. Pet food scientists have learned that it's possible to take a mixture of inedible scraps, fortify it with artificial vitamins and minerals, preserve it so that it can sit on the shelf for more than a year, add dyes to make it attractive, and then extrude it into whimsical shapes that appeal to the human consumer. For this, pet food companies can expect to earn $9 billion in sales in 1996.

 

Scraps and Byproducts

For years, many care givers have tried to avoid feeding their companion animals people food leftovers, having been warned by veterinarians about the heath problems they can cause. Yet much scrap material from the human food industry is ending up in dogs and cats dinner bowls. What the consumer purchases and what the manufacturer advertises are often two entirely different products, and this difference threatens the animals healthy, especially as they age. Learning to read ingredient labels and taking the time to read them carefully is crucial to making an educated choice when purchasing pet food. Ingredients are listed in descending order of weight (heaviest first) under standards established by the Center for Veterinary Medicine for the Food and Drug Administration (FDA). The name of the product (in most states) is dictated by the regulations of the American Association of Feed Control Officials (AAFCO). The trouble is, AAFCO standards can lead to deceptive product names due to the weight and volume variations between wet and dry ingredients. Also, the average consumer has no idea what the definitions for the listed ingredients mean. Preservatives, vitamins, minerals, flavorings, and cereal make up most of what the companion animal eats.

It is not happenstance that four of the top five major pet food companies in the United States are subsidiaries of major multinational food production companies: Colgate Palmolive (which produces Hills Science Diet), Heinz, Nestle, and Mars )see The Corporate Connection). From a business standpoint, multi-national food companies owning pet food manufacturers is an ideal relationship. The multinationals have captive market in which to dump their waste products, and the pet food manufacturers have a direct source of bulk materials. Both make a profit from selling scraps that originate from places far worse than the dinner table. In his 1986 book Pet Allergies veterinarian Al Plechner sums up what goes into companion animals food: Condemned parts and animals rejected for human consumption are routinely rerouted for commercial pet foods. A similar fate applies to so-called 4-D animals. These are food animals picked up dead, or that are dying, diseased, or disabled, and do not meet human-food qualifications. They are processed straightaway for companion animal consumption. Little goes to waste. Says Plechner, Food processing refuse of all sorts winds up in your animals dinner bowls. Moldy grains. Rancid foods. Meat meal. The latter is ground-up slaughterhouse discards often containing disease-ridden tissue and high levels of hormones and pesticides, the very things that may have contributed to the death of the steer or hog. A decade later, his words still apply. When cattle, swine, chickens, lambs, or other animals meet their ends at a slaughterhouse, the choice cuts -- lean muscle tissue and organs prized by humans -- are trimmed away from the carcass for human consumption. Whatever remains of the carcass (bones, blood, pus, intestines, ligaments, subcutaneous fat, hooves, horns, beaks, and any other parts not normally consumed by humans) is, according to the pet food industry, perfectly fit as a protein source for cat and dog food.

The Pet Food Institute, the trade association of pet food manufacturers, acknowledges in its 1994 Fact Sheet the importance of using byproducts in pet foods as additional income for processors and farmers. The purchase and use of these ingredients by the pet food industry not only provides nutritional foods for pets at reasonable costs, but provides an important source of income to American farmers and processors of meat, poultry, and seafood products for human consumption. Many of these remnants are indigestible and provide a questionable source of nutrition. The amount of nutrition provided by meat byproducts, meals, and digests varies from vat to vat of this animal protein soup. A vat filled with chicken feet, beaks, and viscera is going to make available a lower amount of protein than a vat of breast meat. James Morris and Quinton Rogers, professors with Department of Molecular Biosciences at the University of California at Davis Veterinary School of Medicine, assert that there is virtually no information on the bio-availability of nutrients for companion animals in many of the common dietary ingredients used in pet foods. These ingredients are generally byproducts of the meat, poultry and fishing industries, with the potential for wide variation in nutrient composition. Claims of nutritional adequacy of pet foods based on the current AAFCO nutrient allowances (profiles) do not give assurances of nutritional adequacy and will not until ingredients are analyzed and bioavailability values are incorporated. Meat byproducts, the catch-all term of the pet food industry, is a misnomer because these byproducts contain little if any meat. Byproducts contain little if any meat. Byproduct are animal parts leftover after the meat has been stripped from the bone. Chicken byproducts include heads, feet, entrails, lungs, spleens, kidneys, brains, livers, stomachs, noses, blood, and intestines free of their contents. What the pet food manufactures fail to mention is that most byproducts, digests and meals are also filled with other substances, such as cancerous tissue cut from the carcass, plastic foam packaging containing spoiled meat from supermarkets, ear tags, spoiled slaughterhouse meat, road kill, and pieces of downer animals.

 

Canned Cannibalism

Another source of meat that isn't mentioned on pet food labels is pet byproducts, the bodies of dogs and cats. In 1990 the San Francisco Chronicle reported that euthanized companion animals were found in pet foods. Although pet food company executives and the National Renderers Association vehemently denied the report, the American Veterinary Medical Association and the FDA confirmed the story. The pets serve a viable purpose by providing foodstuff for the animal feed chain, said Lea McGovern, chief of the FDA's animal feed safety branch. Because of the sheer volume of animals rendered and the similarity in protein content between poultry byproducts and processed dogs and cats, rendering plant workers say it would be impossible for purchasers to know the exact contents of what they buy. In fact, Sacramento Rendering cited by inspectors five times in the past two years for product-labeling violations.


Grease and Grain

The most nutritious dry pet food is no better than the worst if an animals will not eat it. Pet food scientists have discovered that spraying the kibble or pellets with a combination of refined animal fat, lard, kitchen grease, and other oils too rancid or deemed inedible for humans makes an otherwise bland or distasteful product palatable. Animal fat is mainly packing house waste or supermarket trimmings from the packaging of meats. Animals love the taste of this sprayed fat, which also acts as a binding agent to which manufacturers may add other flavor enhancers. The pungent odor wafting from an open bag of pet food is created by this concoction. Restaurant grease has become a major component of feed-grade animal fat over the last 15 years. Often held in 50-gallon drums for weeks or months in extreme temperatures, this grease is usually kelp outside with no regard for its safety or further use. The rancid grease is then picked up by fat blenders who mix the animal and vegetable fats together, stabilize them with powerful antioxidants to prevent further spoilage, and then sell the blended products to pet food companies. Rancid, heavily preserved fats are extremely difficult to digest and can lead to a host of animal health problems, including digestive upsets, diarrhea, gas, and bad breath. Once considered a filler by the pet food industry, the amount of grain products included in pet food has risen over the last decade as the American population has focused its attention away from consuming beef and toward a healthier diet of grains and vegetables. Commonly two of the top three pet food ingredients are some form of grain products. For instance, Alpo's Beef Flavored Dinner lists ground yellow corn, soybean meal, and poultry byproduct meal as its top three ingredients. 9 Lives Crunchy Meals lists ground yellow corn, corn gluten meal, and poultry byproduct meal as its top three ingredients. Of the top four ingredients of Purina's O.N.E. Dog Formula -- chicken, ground yellow corn, ground wheat, and corn gluten meal -- two are corn-based products from the same source. This is an industry practice known as splitting. When components of the same whole ingredient are listed separately (ground yellow corn and corn gluten meal) it appears that there is less corn than chicken, even when the whole ingredient may weigh more than the chicken. Soy is another common ingredient in many pet foods. It is used by the manufacturers to boost the claimed protein content and add bulk so that when animals eat a product containing soy they will fell more sated. Tofu is suitable for humans, but most forms of soybean do not agree with a dog or cat's digestive system. Like many other pet food ingredients, soy is virtually unusable by an animal's body. Being obligate carnivores, cats have little ability to digest any nutrients from soy. The problem is worse for dogs because they lack the essential amino acid to digest soy products. Soy has also been linked to bloat and gas in many dogs.

 

Additives and Processing

Pet food industry critics note that many of the ingredients (such as corn syrup and corn gluten meal) used as humectants to prevent oxidation also bind water molecules in such a way that the food actually sticks to the animal's colon and may cause blockage. Blockage of the colon may cause an increased risk of cancer of the colon or rectum. Two-thirds of the pet food manufactured in the United States contains synthetic preservatives added by the manufacturer. Of the remaining third, 90 percent includes ingredients already stabilized by synthetic preservatives. Because most pet food contains large percentages of added fat, a stabilizer is needed to maintain the quality of the food. Sodium nitrite, often used as a coloring agent, fixative, and preservative, has the ability to combine with natural stomach and food chemicals (secondary amends) to create nitrosamines, powerful cancer-causing agents, according to A Consumer's Dictionary of Food Additives.

Many pet foods advertised as preservative-free do not contain preservatives. Almost all rendered meats have synthetic preservatives added as stabilizer, but manufacturers aren't required to list preservatives they themselves haven't added. Premixed vitamin additives can also contain preservatives. In the 1003 Journal of the American Veterinary Medical Association, veterinarian Philip Roudebush reported finding low concentrations of synthetic antioxidant preservatives in all analyzed samples of products labeled as chemical free or all-natural. Other types of additives depend on whether the pet food is semi-moist, dry or canned. Because semi-moist food contains 25-50 percent water, antimicrobial preservatives must be used. Propylene glycol was frequently used in cat food until it was pulled in 1992 for causing a variety of health problems. Processing greatly alters the nutritional value of the food ingredients. Veterinarian R. L. Wysong states in Rationale for Animal Nutrition: Processing is the wild card in nutritional value that is, by and large, simply ignored. Heating, freezing, dehydrating, canning, extruding, pelleting, baking and so forth, are so commonplace that they are simply thought of as synonymous with food itself. Because the ingredients that pet food companies use are not wholesome, and harsh manufacturing practices destroy what little nutritional value the food may have had in the first place, the final product must be fortified with vitamins and minerals.

 

Questionable Nutrition

How, then, can any pet food be guaranteed to be 100 percent complete or nutritionally adequate? As long as it meets the AAFCO minimum standards, such a guarantee can be on the label. Yet in 1994, feed tests conducted by the New York State Agriculture Department showed 7 percent of all pet foods analyzed failed chemical analyses for guaranteed nutrients. Other states report similar findings, with failure of analyzed feed ranging from to 12 percent. Even if a pet food meets AAFCO standards, certain nutritional requirements (for example, lysine) can vary between species by as much as seven-fold. Although manufacturers clam that millions of companion animals can thrive on a diet consisting of nothing by commercial pet food, research and an increasing number of veterinarians implicate processed pet food as a source of disease or as an exacerbating agent for a number of degenerative diseases. For example, kidney disease is on of the top three killers of companion animals.  According to Plechner, the extra protein and harsh ingredients of many pet foods place an overload on the kidneys. Left untreated, the toxic buildup leads to vomiting, loss of appetite, uremic poisoning, and death. Wysong adds, In the last few years, large statistical studies have shown the link between the diet (of processed foods) and a variety of degenerative diseases, including cancer, heart disease, allergies, arthritis, obesity, dental disease, etc. After extensive research, the Animal Protection Institute (API) published a Pet Food Investigative Report to educate companion animal care givers about pet food ingredients, ingredient definitions, labeling, and dietary ailments resulting from processed commercial pet food, including the most commonly know brands. Yet, whether such food is purchased at the supermarket, pet store, or from a veterinarian, it makes little difference in terms of the quality -- only in the cost. Since the report was published earlier this year, API has conducted more research on holistic pet care and pet food alternatives, but still claims that the vast majority of pet foods available on the market today provide less that optimum nutrition for companion animals.

It is sad to think that the food provided by animal care givers to their four-legged friends could be hazardous to the animals'; health and longevity. Care givers should assume responsibility for providing as healthful a diet as possible for the animals in the care. Consumers should be informed: speak with a holistic practitioner or herbalist, or consult your veterinarian (but be aware that a veterinarian's knowledge of nutrition may be limited to the two weeks of nutrition he or she had veterinary school 20 years ago). Although the ideal solution would be for companion animals to be fed only wholesome homemade and/or vegetarian diets, this is not an optician for everyone -- the cost and time commitment is sometimes prohibitive. By taking more moderate steps, however, care givers can still greatly improve a companion animals' diet and quality of life.

Tina Perry is an animal advocate with the Animal Protection Institute.
Reprinted from The Animals' Agenda
Nov/Dec 1996

We are very happy to report that HealthyPetNet's Life's Abundance and Flint River Ranch  contain NONE of the things you have read about above, only human-grade, whole ingredients!!!

 

 

(Don't read if you have a weak stomach)

 

The Dark Side of Recycling - Rendering Plants
from Earth Island Journal

 

"The rendering plant floor is piled high with ’raw product’: thousands of dead dogs and cats; heads and hooves from cattle, sheep, pigs and horses; whole skunks; rats and raccoons --all waiting to be processed. In the 90-degree heat, the piles of dead animals seem to have a life of their own as millions of maggots swarm over the carcasses.

"Two bandanna-masked men begin operating Bobcat mini-dozers, loading the ‘raw’ into a 10-foot-deep stainless-steel pit. They are undocumented workers from Mexico, doing a dirty job. A giant auger-grinder at the bottom of the pit begins to turn. Popping bones and squeezing flesh are sounds from a nightmare you will never forget.

"Rendering is the process of cooking raw animal material to remove the moisture and fat. The rendering plant works like a giant kitchen. The cooker, or ‘chef,’ blends the raw product in order to maintain a certain ratio between the carcasses of pets, livestock, poultry waste and supermarket rejects.

"Once the mass is cut into small pieces, it is transported to another auger for fine shredding. It is then cooked at 280 degrees for one hour. The continuous batch cooking process goes on non-stop 24 hours a day, seven days a week as meat is melted away from bones in the hot 'soup.’ During this cooking process, the soup produces a fat of yellow grease or tallow that rises to the top and is skimmed off. The cooked meat and bone are sent to a hammermill press, which squeezes out the remaining moisture and pulverizes the product into a gritty powder. Shaker screens sift out excess hair and large bone chips. Once the batch is finished, all that is left is yellow grease, meal and bone meal.

"As the American Journal of Veterinary Research explains, this recycled meat and bone meal is used as ‘a source of protein and other nutrients in the diets of poultry and swine and in pet foods, with lesser amounts used in the feed of cattle and sheep. Animal fat is also used in animal feeds as an energy source.’ Every day, hundreds of rendering plants across the United States truck millions of tons of this ‘food enhancer’ to poultry ranches, cattle feed-lots, dairy and hog farms, fish-feed plants and pet-food manufacturers where it is mixed with other ingredients to feed the billions of animals that meat-eating humans, in turn, will eat.

"Rendering plants have different specialties. The labeling designation of a particular ‘run’ of product is defined by the predominance of a specific animal. Some product-label names are: meat meal, meat by-products, poultry meal, poultry by-products, fish meal, fish oil, yellow grease, tallow, beef fat and chicken fat.

"Rendering plants perform one of the most valuable functions on Earth: they recycle used animals. Without rendering, our cities would run the risk of becoming filled with diseased and rotting carcasses. Fatal viruses and bacteria would spread uncontrolled through the population.

"Death is the number one commodity in a business where the demand for feed ingredients far exceeds the supply of raw product. But this elaborate system of food production through waste management has evolved into a recycling nightmare. Rendering plants are unavoidably processing toxic waste.

"The dead animals (the ‘raw’) are accompanied by a whole menu of unwanted ingredients. Pesticides enter the rendering process via poisoned livestock, and fish oil laced with bootleg DDT and other organophosphates that have accumulated in the bodies of West Coast mackerel and tuna.

"Because animals are frequently shoved into the pit with flea collars still attached organophosphate-containing insecticides get into the mix as well. The insecticide Dursban arrives in the form of cattle insecticide patches. Pharmaceuticals leak from antibiotics in livestock, and euthanasia drugs given to pets are also included. Heavy metals accumulate from a variety of sources: pet ID tags, surgical pins and needles.

"Even plastic winds up going into the pit. Unsold supermarket meats, chicken and fish arrive in styrofoam trays and shrink wrap. No one has time for the tedious chore of unwrapping thousands of rejected meat-packs. More plastic is added to the pits with the arrival of cattle ID tags, plastic insecticide patches and the green plastic bags containing pets from veterinarians.

"Skyrocketing labor costs are one of the economic factors forcing the corporate flesh-peddlers to cheat. It is far too costly for plant personnel to cut off flea collars or unwrap spoiled T-bone steaks. Every week, millions of packages of plastic-wrapped meat go through the rendering process and become one of the unwanted ingredients in animal feed.

"The most environmentally conscious state in the nation is California, where spot checks and testing of animal-feed ingredients happen at the wobbly rate of once every two-and-a-half months. The supervising state agency is the Department of Agriculture's Feed and Fertilizer Division of Compliance. Its main objective is to test for truth in labeling: does the percentage of protein, phosphorous and calcium match the rendering plant's claims; do the percentages meet state requirements? However, testing for pesticides and other toxins in animal feeds is incomplete.

"In California, eight field inspectors regulate a rendering industry that feeds the animals that the state's 30 million people eat. When it comes to rendering plants, however, state and federal agencies have maintained a hands-off policy, allowing the industry to become largely self-regulating. An article in the February 1990 issue of Render, the industry's national magazine, suggests that the self-regulation of certain contamination problems is not working.

"One policing program that is already off to a shaky start is the Salmonella Education/Reduction Program, formed under the auspices of the National Renderers Association. The magazine states that ‘...unless US and Canadian renderers get their heads out of the ground and demonstrate that they are serious about reducing the incidence of salmonella contamination in their animal protein meals, they are going to be faced with...new and overly stringent government regulations.’

"So far, the voluntary self-testing program is not working. According to the magazine, ‘...only about 20 per cent of the total number of companies producing or blending animal protein meal have signed up for the program...’ Far fewer have done the actual testing.

"The American Journal of Veterinary Research conducted an investigation into the persistence of sodium pentobarbital in the carcasses of euthanized animals at a typical rendering plant in 1985 and found ‘... virtually no degradation of the drug occurred during this conventional rendering process...’ and that ‘...the potential of other chemical contaminants (e.g., heavy metals, pesticides and environmental toxicants, which may cause massive herd mortalities) to degrade during conventional rendering needs further evaluation.’

"Renderers are the silent partners in our food chain. But worried insiders are beginning to talk, and one word that continues to come up in conversation is ‘pesticides.’ The possibility of petrochemically poisoning our food has become a reality. Government agencies and the industry itself are allowing toxins to be inadvertently recycled from the streets and supermarket shelves into the food chain. As we break into a new decade of increasingly complex pollution problems, we must rethink our place in the environment. No longer hunters, we are becoming the victims of our technologically altered food chain.

"The possibility of petrochemically poisoning our food has become a reality."

That article is one of the most disgusting things we have ever read.

"In the U.S., plants process billions of pounds of protein from dead cows, sheep, pigs, chickens and other animals into animal feed each year.

Farmer Carter doesn’t mention this, but reporters Satchell and Hedges do: "Chicken manure often contains campylobacter and salmonella bacteria, which can cause disease in humans, as well as intestinal parasites, veterinary drug residues, and toxic heavy metals such as arsenic, lead, cadmium, and mercury. These bacteria and toxins are passed on to the cattle and can be cycled to humans who eat beef contaminated by feces during slaughter."

If they’re not being fed on rendered by-products or chicken manure, according to the Satchell and Hedges article, "Animal-feed manufacturers and farmers also have begun using or trying out dehydrated food garbage, fats emptied from restaurant fryers and grease traps, cement-kiln dust, even newsprint and cardboard that are derived from plant cellulose. Researchers in addition have experimented with cattle and hog manure, and human sewage sludge. New feed additives are being introduced so fast, says Daniel McChesney, head of animal-feed safety for the U.S. Food and Drug Administration, that the government cannot keep pace with new regulations to cover them."

Cattle and hog manure and human sewage sludge as possible foods for the animals eaten by human beings.

Words fail me.

 

 

 

 

 

 

 

February 28, 2002
Edited for Typographical Errors, March 1, 2002


Food and Drug Administration/Center for Veterinary Medicine
Report on the risk from pentobarbital in dog food

The low levels of exposure to sodium pentobarbital (pentobarbital) that dogs might receive through food is unlikely to cause them any adverse health effects, Food and Drug Administration scientists concluded after conducting a risk assessment. 

During the 1990s, FDA’s Center for Veterinary Medicine (CVM) received reports from veterinarians that pentobarbital, an anesthetizing agent used for dogs and other animals, seemed to be losing its effectiveness in dogs. Based on these reports, CVM officials decided to investigate a plausible theory that the dogs were exposed to pentobarbital through dog food, and that this exposure was making them less responsive to pentobarbital when it was used as a drug.

The investigation consisted of two parts. First, CVM had to determine if dog food could contain residues of the drug. Second, if residues were found, the Center had to determine what risk, if any, the residues posed to dogs.

In conjunction with this investigation, the Center wanted to determine if pet food contained rendered remains of dogs and cats.

How pentobarbital can get into dog food

Because in addition to producing anesthesia, pentobarbital is routinely used to euthanize animals, the most likely way it could get into dog food would be in rendered animal products.

Rendered products come from a process that converts animal tissues to feed ingredients. Pentobarbital seems to be able to survive the rendering process. If animals are euthanized with pentobarbital and subsequently rendered, pentobarbital could be present in the rendered feed ingredients.

In order to determine if pentobarbital residues were present in animal feeds, CVM developed a sophisticated process to detect and quantify minute levels – down to 2 parts per billion of pentobarbital in dry dog food. To confirm that the methods they developed worked properly, CVM scientists used the methods to analyze dry commercial dog foods purchased from retail outlets near to their Laurel, MD, laboratories. The scientists purchased dog food as part of two surveys, one in 1998 and the second in 2000. They found some samples contained pentobarbital (see the attached tables).

Dogs, cats not found in dog food

Because pentobarbital is used to euthanize dogs and cats at animal shelters, finding pentobarbital in rendered feed ingredients could suggest that the pets were rendered and used in pet food. 

- 2 -

CVM scientists, as part of their investigation, developed a test to detect dog and cat DNA in the protein of the dog food. All samples from the most recent dog food survey (2000) that tested positive for pentobarbital, as well as a subset of samples that tested negative, were examined for the presence of remains derived from dogs or cats. The results demonstrated a complete absence of material that would have been derived from euthanized dogs or cats. The sensitivity of this method is 0.005% on a weight/weight basis; that is, the method can detect a minimum of 5 pounds of rendered remains in 50 tons of finished feed. Presently, it is assumed that the pentobarbital residues are entering pet foods from euthanized, rendered cattle or even horses. 

Finding levels of pentobarbital residues in dog food

Upon finding pentobarbital residues in dog food, the researchers undertook an assessment of the risk dogs might face. Dogs were given known quantities of pentobarbital for eight weeks to determine if consumption of small amounts of pentobarbital resulted in any physiological changes that could indicate potential effects on health. In short, the scientists wanted to find the level of pentobarbital dogs could be exposed to that would show no biological effects. The most sensitive indicator that pentobarbital had an effect is an increase in the production of certain enzymes collectively called cytochrome P450.

Virtually all animals produce enzymes as a normal response to metabolize naturally occurring and man-made chemicals in their environment. Barbituates, such as pentobarbital, are especially efficient at causing the liver to produce these enzymes. In dogs, the most sensitive biological response to pentobarbital is an increase in the production of cytochrome P450 enzymes, which is why the scientists chose that as the best indicator of biological effect. If a low level of pentobarbital did not cause a dog to produce additional cytochrome P450 enzymes, then scientists could assume that the pentobarbital at that low level had no significant effect on the dog.

In CVM’s study, experimental animals were each dosed orally with either 50, 150, or 500 micrograms pentobarbital/day for eight weeks. The results were compared with control animals, which were not exposed to pentobarbital.

Several significant pentobarbital-associated effects were identified in this study:
1. Dogs that received 150 and 500 micrograms pentobarbital once daily for eight weeks had statistically higher liver weights (relative to their bodyweights) than the animals in the control groups. Increased liver weights are associated with the increased production by the liver of cytochrome P450 enzymes;
2. An analysis showed that the activity of at least three liver enzymes was statistically greater than that of the controls at doses of approximately 200 micrograms pentobarbital per day or greater.

- 3 -


But researchers found no statistical differences in relative liver weight or liver enzyme activity between the group receiving 50 micrograms pentobarbital per day and the controls. Based on the data from this study, CVM scientists were able to determine that the no-observable-effect level – which is the highest dose at which no effects of treatment were found – for pentobarbital was 50 micrograms of pentobarbital per day.

Adverse health effects unlikely

For the purposes of CVM’s assessment the scientists assumed that at most, dogs would be exposed to no more than 4 micrograms/kilogram body weight/day based on the highest level of pentobarbital found in the survey of dog foods. In reality, dogs are not likely to consume that much. The high number was based on the assumption that the smallest dogs would eat dog food containing the greatest amount of pentobarbital detected in the survey of commercial pet foods-- 32 parts per billion.

However, to get to the exposure level of 50 micrograms of pentobarbital per day, which is the highest level at which no biological response was seen, a dog would have to consume between 5 to 10 micrograms of pentobarbital per kilogram of body weight. But the most any dog would consume, based on the survey results, was 4 micrograms pentobarbital per kilogram of body weight per day.

It should be emphasized that induction of cytochrome P450 enzymes is a normal response to many substances that are naturally found in foods. It is not an indication of harm, but was selected as the most sensitive indicator to detect any biological effect due to pentobarbital.

Thus, the results of the assessment led CVM to conclude that it is highly unlikely a dog consuming dry dog food will experience any adverse effects from exposures to the low levels of pentobarbital found in CVM’s dog food surveys. 

http://www.fda.gov/fdac

 

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